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AMPK activation, glucose management, and the TAME trial anchor.
Insulin is the Traffic Cop directing sugar (cars) into muscle/fat (parking lots). When the cop is tired (Insulin Resistance), cars jam the highway (High Blood Sugar). These agents help restore order.
Triggered by Metformin, Fasting, Exercise.
"Clean up and burn fuel." Anti-cancer, Anti-aging.
Triggered by Protein, Insulin.
"Build muscle and divide." Anabolic.
Taking Metformin post-workout blunts the mTOR signal, potentially reducing muscle growth. Take Metformin away from training (morning or bedtime).
| Agent | Mechanism | Pros | Cons |
|---|---|---|---|
| Metformin | AMPK Activator | ✓ Most studied longevity drug. Cheap. | ⚠️ GI issues. Blunts muscle growth. |
| Berberine | "Natural Metformin" | ✓ No Rx needed. Lowers lipids. | ⚠️ Poor bioavailability (use Dihydro). |
| Acarbose | Blocks Carb Digestion | ✓ Reduces post-meal spikes massively. | ⚠️ Gas/Bloating. |
| SGLT2i (Canagliflozin) | Pee out sugar | ✓ Strong life extension signal (ITP). | ⚠️ UTI risk. Dehydration. |